Status:
ENROLLING_BY_INVITATION
TUS to Disrupt Pathological Oscillations
Lead Sponsor:
University of Oxford
Conditions:
Parkinson Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Scientists and clinicians are interested in measuring and perturbing the signals in the brain - both to better understand normal operation and explore new therapy options for disease. One example of a...
Detailed Description
Transcranial Ultrasound Stimulation (TUS): TUS will be applied using a commercially available transcranial ultrasound transducer and neuronavigation system that allows for targeting of specific brain...
Eligibility Criteria
Inclusion
- Participant is willing and able to give informed consent for participation in the study.
- Male or Female, aged 18 years or above.
- Implanted Medtronic Percept or equivalent DBS system (one that can measure LFPs) or externalised depth electrodes as part of routine care
- Participant willing and able to tolerate transcranial ultrasound stimulation.
- Stable therapy with no drug changes in past 6 weeks
- Measurable beta peak on screening
Exclusion
- Patients with extreme language barrier that cannot understand the purpose or instructions of the study despite the use of an interpreter.
- Patients with implanted electrodes without telemetric capacity.
- Co-morbid neurological disorder that may confound results, e.g. second motor impairment.
- Fever at time of study visit (\>38 degrees Celsius)
Key Trial Info
Start Date :
February 28 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 9 2028
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06932185
Start Date
February 28 2024
End Date
July 9 2028
Last Update
April 17 2025
Active Locations (1)
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1
University of Oxford
Oxford, United Kingdom, OX39DU