Status:
RECRUITING
Immune-mediated Pathogenic Mechanisms of Neuro-PASC in Veterans
Lead Sponsor:
VA Office of Research and Development
Collaborating Sponsors:
James H. Quillen Department of Veterans Affairs Medical Center
Conditions:
Neuro-PASC
Long COVID
Eligibility:
All Genders
18-80 years
Brief Summary
Mental health symptoms, including cognitive impairment ("brain fog"), following COVID-19 are of great concern to Veterans. The investigators' research seeks to advance understanding of the long-term e...
Detailed Description
The goal of this research project is to identify the neuroinflammatory mechanisms contributing to post-COVID cognitive deficits and neuropsychiatric symptoms \[neuro-PASC (post-acute sequelae of SARS ...
Eligibility Criteria
Inclusion
- Eligible participants will:
- have a history of SARS-CoV-2 infection 4 weeks prior to enrollment, defined as a positive PCR or home antigen test
- be able to give informed consent as determined by brief cognitive exam and evaluation of understanding of the risks, benefits, and voluntary nature of the study
- Additionally, participants enrolled as part of the neuro-PASC group must also:
- currently experience neuro-PASC symptoms, not present prior to infection, as confirmed by the "Long COVID-19 Symptom Assessment" scale, a self-report measure that consists of 46 common COVID-19 sequela symptoms
Exclusion
- Exclusion criteria for all groups:
- diagnosed with dementia, traumatic brain injury, a neurological syndrome (e.g. Parkinson disease, Alzheimer disease), or other progressive cognitive disorder before SARS-CoV-2 infection
- diagnosed with a mood or psychotic disorder before SARS-CoV-2 infection
- history of fibromyalgia or chronic fatigue syndrome prior to SARS-CoV-2 infection
- unstable medical conditions or active uncontrolled autoimmune or inflammatory conditions
Key Trial Info
Start Date :
February 20 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 31 2028
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06932237
Start Date
February 20 2025
End Date
March 31 2028
Last Update
April 20 2025
Active Locations (2)
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1
VA Portland Health Care System, Portland, OR
Portland, Oregon, United States, 97207-2964
2
James H. Quillen VA Medical Center, Mountain Home, TN
Mountain Home, Tennessee, United States, 37684