Status:
NOT_YET_RECRUITING
The Therapeutic Effect of Curcumin in Nanogels Compared to 0.1% FAO in the Management of Oral Lichen Planus
Lead Sponsor:
Chulalongkorn University
Conditions:
Oral Lichen Planus
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This randomized, double-blind clinical trial evaluates the therapeutic effects of curcumin in nanogels compared to 0.1% fluocinolone acetonide oral paste in the management of atrophic-erosive oral lic...
Detailed Description
Oral lichen planus (OLP) is a chronic, immune-mediated inflammatory condition that causes painful mucosal lesions and significantly impairs patients' quality of life. Although topical corticosteroids ...
Eligibility Criteria
Inclusion
- Age 18 years or older
- Ability to provide written informed consent
- Clinically and histopathologically confirmed diagnosis of erosive or atrophic oral lichen planus (OLP)
- Presence of symptoms (NRS pain score \> 0 at baseline)
- Ability to communicate and follow instructions
- Willingness to apply oral paste treatment and comply with study protocol
Exclusion
- Pregnancy or lactation
- Current orthodontic treatment
- Uncontrolled diabetes mellitus (HbA1c \> 7% or FPG \> 130 mg/dL)
- Use of anticoagulants or antiplatelet agents
- Severe dry mouth (Challacombe score \> 7)
- History of gastric ulcers, duodenal ulcers, or gallstones
- Presence of any active malignancy or infection
- Use of topical/systemic treatment for OLP in the past 2 weeks
- Current use of immunosuppressants
- Known allergy to corticosteroids or herbal agents such as turmeric
- Diagnosis of oral lichenoid contact lesion or graft-versus-host disease (GVHD)
- History of allogeneic bone marrow transplantation
- Current smokers
Key Trial Info
Start Date :
June 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06932848
Start Date
June 1 2025
End Date
June 30 2026
Last Update
April 22 2025
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.