Status:
NOT_YET_RECRUITING
Losartan to Improve Outcomes After Multi-ligament Knee Injury
Lead Sponsor:
Brigham and Women's Hospital
Collaborating Sponsors:
University of Kentucky
Walter Reed National Military Medical Center
Conditions:
Multi-ligament Knee Injury
Eligibility:
All Genders
18-40 years
Phase:
PHASE2
Brief Summary
Multi-ligament knee injuries (MLKIs) can occur during military training, sports injuries, or traumatic events such as motor vehicle accidents and can be devastating events. These complex injuries invo...
Detailed Description
Whether the result of military training, a sports injury, or trauma, multi-ligament knee injuries (MLKIs) can be devastating events. MLKI treatment is complex and 38% of all patients report postoperat...
Eligibility Criteria
Inclusion
- Multi-ligament knee injury defined as a complete grade III injury of 2 or more ligaments
- At least one ligament surgically reconstructed or repaired
- Willingness to comply with the study protocol and assessments
Exclusion
- Allergic to any active or inactive ingredient of losartan
- Pregnant, planning to become pregnant, or sexually active females choosing not to use effective means of contraception during the 30-day course of losartan
- Those at increased risk of losartan related side effects including those with severe renal insufficiency, hepatic disease, hypotension, and/or hyperkalemia
- Have a history of prior knee ligament surgery of the involved knee
- Undergoing staged surgical procedures in the treatment of MLKI
- Have a traumatic brain injury that limits their ability to participate in their postoperative care or any condition that would preclude the ability to comply with postoperative rehabilitation
- Have a concomitant injury or underwent a surgical procedure that will preclude the ability to perform range of motion exercises (i.e. surgery for extensor mechanism rupture or avulsion, vascular graft surgery)
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2029
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT06933706
Start Date
October 1 2025
End Date
September 30 2029
Last Update
June 27 2025
Active Locations (1)
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1
Mass General Brigham
Foxborough, Massachusetts, United States, 02035