Status:
RECRUITING
Machine Learning Approaches to Personalized Therapy for Advanced Non-small Cell Lung Cancer With Real-World Data
Lead Sponsor:
University of Utah
Collaborating Sponsors:
Patient-Centered Outcomes Research Institute
Conditions:
Non-small Cell Lung Cancer
Eligibility:
All Genders
Brief Summary
This research will leverage machine learning (ML) and causal inference techniques applied to real-world data (RWD) to generate evidence that personalizes treatment strategies for patients with advance...
Detailed Description
The proposed research will enhance patient-centered outcomes research (PCOR) and comparative effectiveness research (CER) methodologies by addressing two key challenges: (1) appropriate handling of mi...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Subjects must meet all of the following eligibility criteria:
- Diagnosed with advanced NSCLC between January 1, 2011, and June 30, 2024.
- Follow-up available until December 31, 2024, with a minimum potential follow-up period of at least six months.
- Exclusion Criteria
- Subjects meeting any of the following criteria at baseline will be excluded:
- Fewer than one day of follow-up post-initiation of first-line (1L) therapy.
- Presence of a targetable mutation, including ALK, BRAF, EGFR, KRAS, or ROS1.
- PD-L1 expression \<50% at baseline (restricted to patients with PD-L1 ≥50%).
- First-line treatment limited to immunotherapy or chemoimmunotherapy (excluding other treatment regimens).
- Patients receiving second-line (2L) treatment, including those enrolled in a clinical study.
Exclusion
Key Trial Info
Start Date :
September 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2026
Estimated Enrollment :
144400 Patients enrolled
Trial Details
Trial ID
NCT06934343
Start Date
September 1 2024
End Date
March 1 2026
Last Update
April 18 2025
Active Locations (1)
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1
Huntsman Cancer Institute at the University of Utah
Salt Lake City, Utah, United States, 84112