Status:
RECRUITING
Subcortical Arousal in Perceptual Awareness
Lead Sponsor:
Yale University
Collaborating Sponsors:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Epilepsy
Eligibility:
All Genders
13+ years
Phase:
NA
Brief Summary
The study is a multi-site study and will be conducted at up to 11 investigative sites in the United States. The study will investigate subcortical arousal circuits in visual perception using technique...
Detailed Description
The study will investigate subcortical arousal circuits in visual perception using techniques with complementary strengths based on promising initial studies. This study is expected to shed important ...
Eligibility Criteria
Inclusion
- The following are the inclusion/exclusion criteria for epilepsy patients with thalamic electrodes age 13 years and up (Aim 1):
- normal vision with or without the use of corrective lenses
Exclusion
- severe vision impairment even with correction preventing ability to see stimuli (prevents accurate pupil and eye gaze measurements)
- unable to perform the perception task due to cognitive impairment. All participants must be capable of consenting for themselves.
- The following are the inclusion/exclusion criteria for epilepsy patients with thalamic electrodes age 18 years and up (Aim 2):
- Inclusion Criteria:
- normal vision with or without the use of corrective lenses
- a female subject must have a negative pregnancy test and if sexually active, must be using a reliable form of birth control for the duration of the trial, be surgically sterile, or be at least two years post-menopausal.
Key Trial Info
Start Date :
October 13 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2030
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT06934356
Start Date
October 13 2025
End Date
December 1 2030
Last Update
November 7 2025
Active Locations (8)
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1
Yale School of Medicine
New Haven, Connecticut, United States, 06520
2
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
3
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
4
Mayo Clinic
Rochester, Minnesota, United States, 55901