Status:
RECRUITING
Effects of Endogenous GIP on Postprandial Blood Pressure in Healthy Individuals
Lead Sponsor:
University Hospital, Gentofte, Copenhagen
Conditions:
Bloodpressure
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
The present study investigates the postprandial role of endogenous glucose-dependent insulinotropic polypeptide (GIP) on cardiovascular haemodynamics, hormone responses, and hypotensive symptoms durin...
Detailed Description
The study is an exploratory, randomised, placebo-controlled, double-blinded crossover study comprising four experimental days. Each experimental day consists of a mixed meal test or drinking water, a ...
Eligibility Criteria
Inclusion
- Age 18-40 years
- BMI between 18.5 and 29.9 kg/m2 (both included)
- Informed consent
Exclusion
- Allergy or intolerance to ingredients included in the mixed meal
- History of Orthostatic Hypotension (OH) or Postural Orthostatic Tachycardia Syndrome (POTS) or other autonomic dysfunction at the discretion of the investigators
- Anaemia (haemoglobin below normal range \<7.3 mmol/L for women and \<8.3 mmol/L for men)
- Kidney disease (estimated glomerular filtration rate (eGFR) \<90 ml/min/1.73 m2) at screening
- Known liver disease and/or elevated plasma alanine aminotransferase (ALT) \> three times the upper limit of normal at screening
- Treatment with antihypertensives
- Treatment with GLP-1RA (Glucagon-like Peptide-1 Receptor Agonist)
- Treatment with SNRI (Serotonin and Noradrenalin Reuptake Inhibitor) or treatment within two weeks before the first experimental day
- Any ongoing medication that the investigator evaluates would interfere with trial participation
- Any physical or psychological condition that the investigator evaluates would interfere with trial participation, including any acute or chronic illnesses
- Any concomitant disease or treatment that, at the discretion of the investigators, might jeopardize the participant's safety during the trial
- Alcohol/drug abuse as per discretion of the investigators
- Pregnancy or breastfeeding
- Participation in any other clinical trial during the study period
- Mental incapacity or language barriers that preclude adequate understanding or cooperation or unwillingness to comply with trial requirements or pr discretion of the investigator
Key Trial Info
Start Date :
May 21 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 31 2026
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT06934473
Start Date
May 21 2025
End Date
January 31 2026
Last Update
September 8 2025
Active Locations (2)
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1
Center for Clinical Metabolic Research
Copenhagen, Hellerup, Denmark, 2900
2
Center for Clinical Metabolic Research
Copenhagen, Hellerup, Denmark, 2900