Status:
NOT_YET_RECRUITING
Oral Melatonin VS Nebulized Dexmedetomidine Premedication on Attenuation of Hemodynamic Response to Direct Laryngoscopy and Tracheal Intubation in Hypertensive Patients
Lead Sponsor:
Tanta University
Conditions:
Tracheal Intubation Morbidity
Laryngoscopy
Eligibility:
All Genders
40-60 years
Phase:
PHASE2
PHASE3
Brief Summary
The aim of this study is to compare the efficacy of oral melatonin versus nebulized dexmedetomidine in attenuating the hemodynamic response to direct laryngoscopy and endotracheal intubation in contro...
Detailed Description
Laryngoscopy and endotracheal intubation are associated with sympathetic stimulation and induce hemodynamic changes with consequent increase in heart rate (HR) and blood pressure (BP) which may lead t...
Eligibility Criteria
Inclusion
- Age (40-60) years of both genders.
- Controlled hypertensive patients.
- Categorized as ASA physical status II.
- Planning to do an elective surgery under General Anesthesia.
Exclusion
- Patient refusal to participate in the study.
- Patient with expected difficult intubation.
- Body Mass Index (BMI) \> 30 kg/m2.
- History of allergy to the drugs of the study.
- Patients with Heart rate\<50 or Heart block.
- End stage renal and hepatic disease.
- Patients on beta blocker, oral hypoglycemics, anti-depressants, anti-convulsants, anti- psychotics and thyroid medications.
- Pregnant or lactating females.
Key Trial Info
Start Date :
April 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2026
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT06935292
Start Date
April 1 2025
End Date
April 1 2026
Last Update
April 20 2025
Active Locations (1)
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1
Tanta University Hospital
Tanta, El-Gharbia Govenorate, Egypt, 31527