Status:
RECRUITING
Deep Brain Stimulation of the Pedunculopontine Nucleus for Alzheimer's Disease
Lead Sponsor:
University Health Network, Toronto
Collaborating Sponsors:
Alzheimer Society of Canada
Brain Canada
Conditions:
Alzheimer Disease
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
Alzheimer's disease (AD) is a brain disorder that gradually impacts cognitive functions such as memory, thinking, and daily functioning. Gamma oscillations are a type of brain activity thought to play...
Detailed Description
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that gradually impairs memory, cognitive abilities, and daily functioning, placing a significant burden not only on patients but al...
Eligibility Criteria
Inclusion
- Adults over 60 years old.
- Diagnosis of Alzheimer's Disease: Satisfied the diagnostic criteria of the National Institute of Aging - Alzheimer's Association criteria for probable AD.
- Clinical dementia rating scale global score of ≤ 1.
- Not taking an acetylcholinesterase inhibitor and/or memantine, or taking a stable dose for at least six months.
- Fluent in English.
- Caregiver available to participate in the study.
Exclusion
- Pre-existing structural brain abnormalities (e.g., significant white matter disease, tumor, infarction, or intracranial hematoma).
- Other neurologic or psychiatric diagnoses, or medical comorbidities that would preclude patients from undergoing surgery.
- Non-fluent in English (it will be very difficult to conduct standard cognitive tests in English on non-fluent English speakers. In addition, language barrier is significant hurdle in providing standard care with communication and cognition being a main outcome measure).
Key Trial Info
Start Date :
May 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2028
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT06936124
Start Date
May 1 2025
End Date
November 1 2028
Last Update
May 1 2025
Active Locations (1)
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1
Toronto Western Hospital
Toronto, Ontario, Canada, M5T 2S8