Status:
NOT_YET_RECRUITING
Comparison of Aquaporin -4, -5, -9 and IL-8 Levels in GCF, Dentin Fluid and Pulp Samples
Lead Sponsor:
Kırıkkale University
Conditions:
Pulpitis
Pulpitis - Irreversible
Eligibility:
All Genders
18-64 years
Brief Summary
This study aimed to compare the changes in AQP -4, -5, -9, and IL-8 levels in pulp tissue, GCF, and dentin fluid samples routinely obtained during the treatment of healthy and symptomatic teeth diagno...
Detailed Description
A total of 70 healthy (Group 1) and symptomatic irreversible pulpitis (Group 2) patients aged 18-64 years, who will undergo routine root canal treatment at Kırıkkale University, Faculty of Dentistry, ...
Eligibility Criteria
Inclusion
- Patients aged 18 to 64 years.
- Patients without any known systemic disease.
- Patients requiring root canal treatment for prosthetic purposes (Healthy pulp group).
- Patients with third molars (wisdom teeth) indicated for extraction due to orthodontic or other clinical reasons (Healthy pulp group).
- Patients diagnosed with symptomatic irreversible pulpitis based on the criteria established by the American Association of Endodontists (AAE) (Symptomatic irreversible pulpitis group).
- Patients scheduled for routine root canal treatment at the Department of Endodontics, Faculty of Dentistry, Kırıkkale University.
- Patients who have provided written informed consent to participate in the study.
Exclusion
- Patients with any known systemic disease.
- Pregnant women or those suspected of being pregnant.
- Patients who have used antibiotics, anti-inflammatory drugs, or antidepressants within the past 4 weeks.
- Patients with significant dental plaque or calculus, gingival redness or bleeding, severe gingivitis, generalized periodontitis, or periodontal pockets deeper than 4 mm.
- Patients with teeth showing internal or external root resorption.
- Patients for whom complete rubber dam isolation cannot be achieved.
- Patients with teeth exhibiting signs of necrosis, apical lesions, swelling, or presence of a sinus tract.
- Patients with immature teeth presenting open apices.
- Patients with third molars (wisdom teeth) that are not fully erupted or have been previously diagnosed with pericoronitis.
Key Trial Info
Start Date :
December 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 12 2026
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT06938191
Start Date
December 1 2025
End Date
September 12 2026
Last Update
December 1 2025
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