Status:
RECRUITING
The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.
Lead Sponsor:
University Hospital, Ghent
Conditions:
Cardiac Arrest (CA)
Out-of-hospital Cardiac Arrest (OHCA)
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The goal of this clinical trial is to learn whether using Positive End-Expiratory Pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves outcomes for adults who experience out-of-hospital...
Detailed Description
Introduction: Sudden cardiac arrest is a significant cause of mortality, with an estimated annual incidence of 84 cases per 100,000 individuals in Europe. Effective cardiopulmonary resuscitation (CPR)...
Eligibility Criteria
Inclusion
- Age: Adults aged 18 years and older.
- Type of Cardiac Arrest: Patients who have experienced a non-traumatic out-of-hospital cardiac arrest.
- CPR Administration: Patients receiving cardiopulmonary resuscitation from an advanced life support (ALS) team.
- Intubation and Ventilation: Patients who are intubated and ventilated during resuscitation efforts.
Exclusion
- Cardiac arrest in patient younger than 18 years of age.
- Traumatic cardiac arrest, including drowning, penetrating or blunt injury, and burns.
- Immediate Return of Spontaneous Circulation (ROSC): Patients who achieve ROSC before intubation and initiation of intubation.
- Pregnancy.
- Mechanical ventilation during arrest: patients already receiving mechanical ventilation at the moment of cardiac arrest, due to reasons other than their arrest, will be excluded.
- Do Not Resuscitate (DNR) Orders: Patients with existing DNR orders or any advanced directive indicating that CPR should not be performed.
- Failure to intubate: if intubation is unsuccessful, ventilation by any means (MBV, SGA) should take priority over the study protocol, and the patient is excluded.
- Enrolment in Other Studies: Patients currently enrolled in another interventional clinical trial that could interfere with the outcomes of this study.
Key Trial Info
Start Date :
April 25 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2027
Estimated Enrollment :
132 Patients enrolled
Trial Details
Trial ID
NCT06939335
Start Date
April 25 2025
End Date
February 1 2027
Last Update
May 13 2025
Active Locations (5)
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1
AZORG: campus Merestraat
Aalst, Belgium, B-9300
2
AZORG: Campus Moorselbaan
Aalst, Belgium, B-9300
3
AZORG: campus Geraardsbergen
Geraardsbergen, Belgium, B-9500
4
UZ Ghent
Ghent, Belgium, B-9240