Status:
RECRUITING
Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation
Lead Sponsor:
University of New Mexico
Collaborating Sponsors:
The Mind Research Network
United States Department of Defense
Conditions:
Long COVID
Long COVID Syndrome
Eligibility:
All Genders
18-80 years
Phase:
PHASE2
Brief Summary
The goal of this clinical trial is to test whether a type of rapid outpatient brain stimulation that uses magnetic fields, called accelerated intermittent theta burst stimulation (iTBS), can treat sym...
Detailed Description
Chronic neuropsychiatric symptoms of post-acute sequelae of COVID-19 (neuro-PASC) can lead to disability, loss of function, and reduced quality of life, but there are currently no validated effective ...
Eligibility Criteria
Inclusion
- aged 18-80
- a documented diagnosis of PASC with evidence of ongoing symptoms as demonstrated by score of 12 on the NIH RECOVER Symptom List
- have "brain fog" or cognitive difficulties as one of the ongoing symptoms
- are fluent in English
- if taking psychotropic medications, have been on stable doses for the past month.
Exclusion
- a prior history of other neurological disease, or any history of seizures, so as to reduce risk of exacerbation of epilepsy or other neurological symptoms;
- history of a psychotic disorder, such as schizophrenia or bipolar disorder, so as to reduce risk of psychiatric decompensation
- history of ongoing substance/alcohol dependence, to reduce confounding effects on diagnosis and brain imaging
- presence of any implanted electrical device (e.g., pacemaker), to reduce risk of device malfunction from rTMS
- recent medical hospitalization (within four weeks), to reduce risk of medical decompensation during the study
- any condition that would prevent the subject from completing the protocol
- appointment of a legal representative, to avoid coercion of a vulnerable population
- any ongoing litigation related to medical diagnosis, or disability, to prevent interference with legal proceedings
- any contraindication to MRI
- membership in an identified vulnerable population, including minors, pregnant women, and prisoners, so as to prevent coercion.
Key Trial Info
Start Date :
July 7 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2029
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06940609
Start Date
July 7 2025
End Date
June 30 2029
Last Update
July 15 2025
Active Locations (1)
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1
University of New Mexico Health Science Center
Albuquerque, New Mexico, United States, 87106