Status:
RECRUITING
Topical 0.5% Timolol Solution for Healing Lower Extremity Wounds
Lead Sponsor:
Icahn School of Medicine at Mount Sinai
Conditions:
Wound Healing
Mohs Micrographic Surgery
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Topical timolol, a β2-Adrenergic receptor (B2AR) antagonist, has demonstrated promise in wound healing over the past several years. The majority of the literature has evaluated the use of topical timo...
Eligibility Criteria
Inclusion
- Be scheduled to undergo MMS at 234 East 85th St for a skin cancer that is deemed Mohs
- Appropriate by the Mohs surgery appropriate use criteria
- Have an open surgical wound \< 4 cm and \> 0.5 cm
- Be ≥18 years of age
- English-speaking
- Provide a signed and dated informed consent form
- State willingness to comply with all study procedures
Exclusion
- Age less than 18 years of age
- Open surgical wound \> 4 cm
- If tumor clearance cannot be achieved with MMS
- Pregnant women
- Breastfeeding women
- Patients who are taking oral beta-blockers (ie oral timolol, metoprolol, carvedilol, propranolol, atenolol)
- Patients who are currently taking any of the following medications: clonidine, digoxin, methyldopa, quinidine, fluoxetine and paroxetine, bupropion
- Patient currently taking a calcium channel blocker AND has pre-existing heart failure as defined by a reduced ejection fraction
- Patients with pre-existing hypotension
- Pre-existing diagnosis of sinus bradycardia
- Pre-existing diagnosis of second or third degree atrioventricular block
- Congestive heart failure
- Pre-existing diagnosis of severe asthma
- Pre-existing diagnosis of chronic obstructive pulmonary disease
- Any known hypersensitivity to 0.5% timolol solution
- Patients who have a wound where primary closure is feasible and desired by the patient
- Defect size \<0.5 cm
- Prior sensitivity or known allergy to timolol
Key Trial Info
Start Date :
January 3 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2026
Estimated Enrollment :
102 Patients enrolled
Trial Details
Trial ID
NCT06941467
Start Date
January 3 2025
End Date
April 1 2026
Last Update
April 23 2025
Active Locations (1)
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1
Mount Sinai
New York, New York, United States, 10028