Status:
NOT_YET_RECRUITING
Cryoneurolysis in Patients Awaiting Total Hip and Knee Arthroplasty
Lead Sponsor:
University of Calgary
Conditions:
Hip Arthropathy
Knee Arthropathy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
During the COVID-19 pandemic, there was a drastic increase in surgical wait times across Canada, notably for patients awaiting total knee and hip arthroplasty. Currently the average wait time for tota...
Eligibility Criteria
Inclusion
- Currently awaiting THA or TKA (have signed consent for surgery)
- Osteoarthritis as a primary diagnosis for THA or TKA
- Currently taking regular daily opioids for at least one month
- No allergies to local aesthetics
- Speaks and understands English
- Over 18 years old
- Lives within a 1-hour distance of the hospital where the study is taking place or willing to travel to the hospital for the interventions and follow up.
Exclusion
- If surgery is expected to be completed within 1 month of the intervention as this would limit our ability to evaluate the effectiveness of the cryoneurolysis procedure
- Allergies to local anesthetics
- Inability to communicate with investigators
- Opioid use disorder
- History of severe psychiatric or medical conditions which hinder effective communication
- Living more than 1 hour away from the hospital where the study is taking place or unable to travel to the hospital for the interventions and follow up
- Body mass Index (BMI) ≥40
- Any contraindications specific to percutaneous cryoneurolysis such as history of bleeding diathesis, any active infections at the procedural site, cold urticaria, cryofibrinogenemia, cryoglobulinemia, paroxysmal cold hemoglobinuria, or Raynaud's disease (see Ilfeld \& Finneran, 2020)
- Use of therapeutic anticoagulation
- Diagnosis of Non-Osteoarthritis as the cause for THA or TKA
- Other chronic pain condition which patients may be taking opioids to control the pain (e.g. Fibromyalgia or Complex Regional Pain Syndrome)
- Less than 50% reduction in pain with diagnostic blocks using 0.5% bupivacaine
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06942078
Start Date
October 1 2025
End Date
December 31 2027
Last Update
September 25 2025
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