Status:
NOT_YET_RECRUITING
PCT Guided Antibiotics Use in Critically Ill Adult Patients in China
Lead Sponsor:
China-Japan Friendship Hospital
Conditions:
Sepsis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Procalcitonin (PCT) has been widely used in the diagnosis and treatment of bacterial infectious diseases in China. The investigators aim to establish an algorithm based on BRAHMS PCT (VIDAS PCT) for p...
Detailed Description
This is a multi-center prospective study that will establish 9 centers. Based on preliminary on-site assessments, the centers will be grouped into two arms (SOC group and PCT group) according to their...
Eligibility Criteria
Inclusion
- Age≥18
- Suspected or confirmed bacterial patients
- Stay EICU more than 3 days
Exclusion
- age under 18 years;
- PCT concentration throughout the entire hospitalization less than 0.5 ng/ml ;
- known pregnancy; expected stay in the EICU less than 3 days;
- bone-marrow transplant or chemotherapy-induced neutropenia (\<500 neutrophils per mL);
- infections for which long-term antibiotic treatment is strongly recommended (ie, infective endocarditis, osteoarticular infections, anterior mediastinitis after cardiac surgery, hepatic or cerebral abscesses, chronic prostatitis, or infection with Mycobacterium tuberculosis, Pneumocystis jirovecii, or Toxoplasma gondii);
- poor chance of survival, defined as a simplified acute physiology score (SAPS II) of more than 65 points at screening; and do-not-resuscitate orders
Key Trial Info
Start Date :
June 30 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
800 Patients enrolled
Trial Details
Trial ID
NCT06945510
Start Date
June 30 2025
End Date
December 31 2026
Last Update
April 25 2025
Active Locations (1)
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1
China-Japan Friendship Hospital
Beijing, China, 100029