Status:
RECRUITING
Rituximab, Methotrexate, and Tepadina Induction Followed by Etoposide and Cytarabine Consolidation in Primary Central Nervous System Lymphoma
Lead Sponsor:
FengYan Jin
Conditions:
Primary Central Nervous System Lymphoma (PCNSL)
CNS Lymphoma Treatment
Eligibility:
All Genders
Up to 60 years
Phase:
NA
Brief Summary
High-dose methotrexate (HD-MTX) remains the foundation of treatment for primary central nervous system lymphoma (PCNSL), but outcomes are suboptimal. The addition of rituximab has shown mixed results,...
Detailed Description
A retrospective analysis conducted at the study center demonstrated an objective response rate (ORR) of 64.3% among patients with primary central nervous system lymphoma (PCNSL) receiving chemotherapy...
Eligibility Criteria
Inclusion
- Age ≤ 60 years, male or female
- Histologically and immunohistochemically confirmed diagnosis of diffuse large B-cell lymphoma (DLBCL) without prior treatment
- No evidence of systemic lymphatic or hematopoietic involvement or other systemic disease, based on thorough physical examination and imaging/laboratory tests
- Diagnosis meets criteria for Primary Central Nervous System Lymphoma (PCNSL)
- Written informed consent obtained from the patient or their legal guardian
- Voluntary agreement to participate in the study
Exclusion
- Presence of another active malignancy
- Known history of HIV infection or diagnosis of acquired immunodeficiency syndrome (AIDS)
- Known allergy to any of the investigational drugs or their excipients
- Any condition that, in the opinion of the investigator, may lead to early study termination, including but not limited to:
- Severe comorbidities
- Significant laboratory abnormalities
- Serious social or family circumstances affecting safety or compliance
Key Trial Info
Start Date :
December 2 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2029
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT06946407
Start Date
December 2 2022
End Date
December 1 2029
Last Update
April 27 2025
Active Locations (1)
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1
Facility Name: The First Hospital of Jilin University
Changchun, China