Status:
COMPLETED
Preoperative Study of the Correlation Between BDNF-TrkB Signaling Pathway Expression Levels in Cerebrospinal Fluid and Blood and Postpartum Depression
Lead Sponsor:
The First People's Hospital of Lianyungang
Conditions:
Postpartum Depression (PPD)
Eligibility:
FEMALE
20-35 years
Brief Summary
This single-center prospective observational study will screen 200 parturients with combined lumbo-epidural anesthesia in the First People's Hospital of Lianyungang City, collect the basic information...
Detailed Description
On the day before delivery, the anterior will explain the purpose of the test to the pregnant woman during the preoperative follow-up, and collect the basic information of the pregnant woman (age, gen...
Eligibility Criteria
Inclusion
- Meet the indications for cesarean section and have no contraindications to neuraxial anesthesia;
- 20 years old≤ age ≤ 35 years old;
- 37≤ gestational age\< 42;
- American Society of Anesthesiologists (ASA) grade II\~III;
- singleton pregnancy;
- Voluntarily participate in this study and sign the informed consent form.
Exclusion
- Unable to understand the content of the questionnaire correctly;
- a clear history of mental illness, depression, cognitive impairment and other diseases;
- Patients who have been taking sedative, analgesic and psychotropic drugs for a long time;
- Those who have recently used glucocorticoids or immunosuppressants;
- Those who are allergic to or have contraindications to any of the drugs used in this study;
- Serious pregnancy complications, such as preeclampsia, placental hyperplasia, etc.;
- Participated in other clinical studies within the last 3 months.
Key Trial Info
Start Date :
May 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 16 2025
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06947278
Start Date
May 1 2025
End Date
November 16 2025
Last Update
December 2 2025
Active Locations (1)
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1
The Affiliated Lianyungang Hospital of Xuzhou Medical University
Lianyungang, Jiangsu, China, 222000