Status:
COMPLETED
Correlation of EtCO₂- and P(A-a)O₂-Based Dead Space Calculations in Mechanically Ventilated ICU Patients
Lead Sponsor:
Karadeniz Technical University
Conditions:
Physiological Dead Space
Ventilation-Perfusion Mismatch
Eligibility:
All Genders
18+ years
Brief Summary
This study aims to evaluate two different methods for calculating physiological dead space in adult patients undergoing invasive mechanical ventilation in the intensive care unit (ICU). Physiological ...
Detailed Description
Physiological dead space (VD/VT) is a key parameter in evaluating the efficiency of gas exchange in mechanically ventilated patients. It represents the fraction of each breath that does not participat...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Admission to the intensive care unit (ICU)
- Receiving invasive mechanical ventilation
- Expected ICU stay ≥ 24 hours
- Availability of both arterial blood gas and volumetric capnography measurements
- Central venous cathater for central venous blood analyses
- Informed consent obtained from legal representative
Exclusion
- Refusal of participation by the patient or legal surrogate
- Hemoglobin \< 7 g/dL
- PaCO₂ \> 70 mmHg
- Lactate \> 4 mmol/L
- Capillary refill time \> 3 seconds
- Mean arterial pressure (MAP) \< 65 mmHg
- Mottling score ≥ 2
- PaCO₂ - PcCO₂ gradient \> 8 mmHg
- pH \< 7.20
- Body temperature \> 38°C
- BMI \> 40 kg/m²
- VCO₂ \> 4 mL/kg/min
- Technical limitations preventing accurate capnographic monitoring
- Patients who are extubated, transferred, or deceased within the first 24 hours
Key Trial Info
Start Date :
January 5 2025
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 18 2025
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT06947486
Start Date
January 5 2025
End Date
April 18 2025
Last Update
April 27 2025
Active Locations (1)
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1
Karadeniz Technical University Faculty of Medicine, Department of Chest Diseases, Intensive Care Unit
Trabzon, Turkey (Türkiye), 61080