Status:
RECRUITING
Pneumatic Leg Compression and Norepinephrine Requirements in Patients Having Non-cardiac Surgery
Lead Sponsor:
Universitätsklinikum Hamburg-Eppendorf
Conditions:
Hypotension During Surgery
Eligibility:
All Genders
45+ years
Phase:
NA
Brief Summary
The PLANE trial is a randomized, single-center trial investigating whether pneumatic leg compression reduces the amount of norepinephrine needed to keep MAP above 65mmHg compared to routine care witho...
Eligibility Criteria
Inclusion
- Consenting patients ≥45 years scheduled for elective non-cardiac surgery under general anesthesia that is expected to last ≥60 minutes
Exclusion
- Patients with the following exclusion criteria:
- Surgery in which pneumatic calve compression is indicated according to ERAS guidelines
- Surgery which interferes with the installation or correct function of PLC
- Sepsis (according to current Sepsis-3 definition)
- Pregnancy
- Congestive heart failure NYHA III/IV
- American Society of Anesthesiologists (ASA) physical status classification V or VI
- Interference of PLC and patient positioning (e.g.; extreme Trendelenburg positioning, lithotomy positioning)
- Contraindications for the use of PLC according to the German guideline13 (e.g., extensive thrombophlebitis, thrombosis or suspected thrombosis of the lower limbs, erysipelas, acute phlegmon, limb compartment syndrome, severe uncontrolled arterial hypertension, lymphatic drainage disorder proximal to PLC, extensive open soft tissue trauma, autoimmune blistering skin conditions such as IgA bullous dermatosis or bullous pemphigoid)
Key Trial Info
Start Date :
May 19 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2025
Estimated Enrollment :
238 Patients enrolled
Trial Details
Trial ID
NCT06950606
Start Date
May 19 2025
End Date
October 1 2025
Last Update
June 8 2025
Active Locations (1)
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1
University Medical Center Hamburg-Eppendorf
Hamburg, Hamburg, Germany, 20246