Status:
ACTIVE_NOT_RECRUITING
Mechanisms of Macrophage Polarization in HIRI in Patients With NAFLD
Lead Sponsor:
Zhifeng Gao
Conditions:
Hepatic Ischemia-reperfusion Injury
Non-alcoholic Fatty Liver Disease
Eligibility:
All Genders
18+ years
Brief Summary
To better understand the occurrence of hepatic ischemia-reperfusion injury (IRI) in patients with non-alcoholic fatty liver disease (NAFLD) and the role of macrophage polarization in this process, thi...
Eligibility Criteria
Inclusion
- The vital organ systems (heart, lungs and kidneys) have sufficient functional reserves.
Exclusion
- No hepatic inflow occlusion (Pringle maneuver) was applied during surgery.
- American Society of Anesthesiologists (ASA) Physical Status Classification \> Grade III.
- Secondary causes of hepatic steatosis were excluded, including viral hepatitis, drug-induced liver injury, total parenteral nutrition, Wilson's disease, and autoimmune liver diseases.
- Prior chemotherapy or radiotherapy before the planned surgery.
- Use of anticoagulant medications.
Key Trial Info
Start Date :
April 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT06950710
Start Date
April 1 2025
End Date
June 30 2026
Last Update
April 30 2025
Active Locations (1)
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1
Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine，Tsinghua University
Beijing, Beijing Municipality, China, 102218