Status:
RECRUITING
Comparison of Phaco Surgery With Goniosynechialysis Versus Trabeculectomy in Glaucoma Treatment
Lead Sponsor:
University of Medicine and Pharmacy at Ho Chi Minh City
Conditions:
Primary Angle Closure Glaucoma
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
The goal of this clinical trial is to learn whether phacoemulsification combined with goniosynechialysis (Phaco-GSL) is as effective and safe as trabeculectomy in treating patients with primary angle-...
Detailed Description
This clinical trial is designed to compare the clinical efficacy and safety of two surgical interventions for patients with primary angle-closure glaucoma (PACG): (1) phacoemulsification combined with...
Eligibility Criteria
Inclusion
- Age ≥ 40 years
- Peripheral anterior synechiae (PAS) \>180°
- Glaucomatous optic neuropathy with visual field loss
- Intraocular pressure (IOP) \> 21 mmHg despite medication
- Ability to consent and comply with follow-up
- Cataract grade 1 to 3 according to LOCS III
- Best corrected visual acuity (BCVA) ≥ 0.3 logMAR (equivalent to 20/40 Snellen or worse)
Exclusion
- Very advanced glaucoma (only light perception vision)
- Secondary angle-closure etiologies
- Prior ocular surgeries or laser peripheral iridotomy (PI)
- Allergy to 5-fluorouracil (5-FU), if used postoperatively
- Irreversible corneal disease
- Chronic corticosteroid use
- Poor follow-up compliance
- Cataract grade 4 or 5 (LOCS III)
- Phacomorphic, phacolytic, or subluxated cataracts
Key Trial Info
Start Date :
June 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 10 2027
Estimated Enrollment :
82 Patients enrolled
Trial Details
Trial ID
NCT06952153
Start Date
June 1 2025
End Date
September 10 2027
Last Update
September 11 2025
Active Locations (1)
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1
HCMC University of Medicine and Pharmacy
Ho Chi Minh City, Vietnam