Status:
COMPLETED
Pericardial Histopathology and COVID-19 Seropositivity
Lead Sponsor:
Samsun University
Conditions:
Inflammatory Response
COVID-19
Eligibility:
All Genders
20-75 years
Brief Summary
This prospective study aims to investigate the association between pericardial histopathologic inflammation grades (acute, chronic, or absent) and COVID-19 seropositivity in adult patients undergoing ...
Eligibility Criteria
Inclusion
- Age ≥20 years
- Undergoing first-time isolated coronary artery bypass grafting (CABG)
- Availability of pericardial tissue sample for histopathological analysis
- Preoperative COVID-19 serological testing performed
- Written informed consent obtained
Exclusion
- Previous history of cardiac surgery (e.g., prior CABG, valve surgery)
- Concomitant cardiac procedures during the same operation (e.g., valve repair, aortic surgery)
- Active COVID-19 infection at the time of surgery (positive PCR test)
- Known autoimmune or systemic inflammatory diseases (e.g., lupus, rheumatoid arthritis)
- Chronic immunosuppressive therapy (e.g., steroids, biologics)
- Known malignancy at the time of surgery
- Insufficient or inadequate pericardial tissue sample for histopathological assessment
Key Trial Info
Start Date :
February 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2024
Estimated Enrollment :
93 Patients enrolled
Trial Details
Trial ID
NCT06952179
Start Date
February 1 2023
End Date
June 1 2024
Last Update
April 30 2025
Active Locations (1)
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1
Samsun University Faculty of Medicine
Samsun, Turkey (Türkiye), 55090