Status:
NOT_YET_RECRUITING
Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD
Lead Sponsor:
Wayne State University
Conditions:
PTSD - Post Traumatic Stress Disorder
Eligibility:
All Genders
18-80 years
Phase:
PHASE1
Brief Summary
The goal of this study is to determine how non-invasive brain stimulation (delivered through the ear called vagus nerve stimulation) affects fear learning processes in people who have experienced psyc...
Detailed Description
This study aims to determine how non-invasive brain stimulation (delivered through the ear) affects learning processes. During this study, participants who have experienced a trauma will be asked to c...
Eligibility Criteria
Inclusion
- Ages 18-80
- Fluent in English
- Experience with a DSM-5 Criterion A trauma (LEC-5)
- Probable PTSD (PCL-5 ≥ 32)
Exclusion
- Visual or Auditory impairment
- Major injury at time of screen or study procedures
- Taking ≥20 mg morphine per day
- Current substance use or intoxication (12-panel drug test)
- Intellectual disability (MoCA)
- Self-inflicted injury
- Occupational injury
- Prisoner
- Ongoing domestic violence
- Pregnant or breastfeeding
- Contraindications for taVNS
Key Trial Info
Start Date :
February 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2032
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06953388
Start Date
February 1 2026
End Date
December 1 2032
Last Update
May 18 2025
Active Locations (1)
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1
Tolan Park Research Clinic, Wayne State University
Detroit, Michigan, United States, 48201