Status:
RECRUITING
Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol Secretion
Lead Sponsor:
Qifu Li
Conditions:
Primary Aldosteronism
Autonomous Cortisol Secretion
Eligibility:
All Genders
18-70 years
Brief Summary
To evaluate the incidence of adrenal insufficiency after surgery in Primary aldosteronism (PA) patients concurrent with or without autonomous cortisol secretion (ACS).
Detailed Description
This study is a prospective, single-center research. Primary aldosteronism patients concurrent with or without autonomous cortisol secretion who underwent adrenalectomy and completed the adrenocortico...
Eligibility Criteria
Inclusion
- PA conccurent with or without autonomous cortisol secretion
- complete adrenalectomy
- complete ACTH stimulation test on the one day after surgery
- complete follow-up at 6，12 months after surgery
Exclusion
- Patients underwent partial adrenalectomy
- Suspicion of familial hyperaldosteronism or Liddle syndrome. \[i.e., age \<20 years, hypertension and hypokalemia, or with family history\]
- Suspicion of pheochromocytoma or adrenal carcinoma.
- Congestive heart failure with New York Heart Association (NYHA) Functional Classification III or IV; History of serious cardiovascular or cerebrovascular disease (angina, myocardial infarction or stroke) in the past 3 months; Severe anemia (Hb\<60g/L); Serious liver dysfunction or chronic kidney disease aspartate aminotransferase (AST) or alanine transaminase (ALT) \>3 times the upper limit of normal, or estimated glomerular filtration rate (eGFR) \< 30 ml/min/1.73 m2); Systemic Inflammatory Response Syndrome (SIRS); Uncontrolled diabetes (FBG≥13.3 mmol/L); Obesity (BMI≥35 kg/m2) or Underweight (BMI≤18 kg/m2); Untreated aneurysm; Other comorbidity potentially interfering with treatment;
- Patients with actively malignant tumor.
- Long- term use of glucocorticoids.
- Suspected PBMAH or PPNAD;
Key Trial Info
Start Date :
January 2 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2028
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06955286
Start Date
January 2 2025
End Date
December 31 2028
Last Update
August 1 2025
Active Locations (1)
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1
the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Chongqing, Chongqing Municipality, China, 400016