Status:
RECRUITING
The Effect of Pectin Supplementation on Geriatric With Frailty: A Randomised Placebo-Controlled Dietary Intervention Study
Lead Sponsor:
University of Nottingham
Conditions:
Frailty at Older Adults
Pre-Frailty
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
The study involves the intake of Low-methoxy (LM) pectin (polysaccharides extracted from citrus peels), which are commonly found in the UK diet (not pharmacological agents), to test their effects on s...
Detailed Description
The overall aim of the proposed project is to study the effect of daily ingestion of a dietary fibre (LM pectin) among frail population on anti-inflammatory and cardioprotective metabolic measures and...
Eligibility Criteria
Inclusion
- Participant is willing and able to give informed consent for participation in the study.
- Participant eligibility includes those aged \>65 years who have a body mass index (BMI) between 18.5 and 39.9 kg/m2.
- Participants who are considered as pre-frail or frail based on FRAIL (Simple Frailty Questionnaire).
Exclusion
- Have gastrointestinal conditions e.g. malabsorptive conditions such as IBS/IBD, coeliac or functional conditions such as gastroparesis or food intolerances etc.
- History of major surgery which potentially limit participation or completion of the study.
- History of gastrointestinal resection surgery, including bariatric surgery.
- Used of antibiotics, antifungal medications, probiotics or prebiotics 90 days before the start of the study.
- Are taking the following medications: immunosuppressants, amiodarone and/or perhexiline.
- Are currently following or anticipated to commence a specialised commercially available weight loss diet and/or program.
- History of side effects towards probiotics or prebiotics.
- History or current psychiatric illness.
- History or current neurological condition (e.g. epilepsy).
- Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance.
Key Trial Info
Start Date :
February 10 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2026
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06955975
Start Date
February 10 2025
End Date
March 31 2026
Last Update
June 22 2025
Active Locations (1)
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1
University of Nottingham
Nottingham, Nottingham, United Kingdom, NG7 2UH