Status:
NOT_YET_RECRUITING
BmemHLA : Origins of the Heterogeneity of the Anti-HLA Memory B Cells in Kidney Transplantation
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Kidney Transplantation
Immunology
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study will describe the transcriptomic and phenotypic characteristics of anti-HLA memory B cells by comparing five groups of patients awaiting renal transplantation: patients with a single histor...
Detailed Description
In kidney transplantation, the production of anti-HLA antibodies directed against the donor (DSA for Donor Specific Antibodies) can be responsible for humoral rejection, the main cause of long-term gr...
Eligibility Criteria
Inclusion
- Adult kidney transplantation candidate at CHU de Bordeaux
- Sensitized against class I HLA
- Only on type of sensitizing event among : transfusion, pregnancy, previous transplantation, no senitizing event
Exclusion
- Pediatric kidney transplantation candidate at CHU de Bordeaux
- Rituximab injection
- Ongoing treatment with immunosuppressive drugs
- Non-cutaneous carcinoma, chronic viral infection
- Acute infection
- Recent vaccination (\<1 month)
Key Trial Info
Start Date :
June 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 15 2028
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT06956469
Start Date
June 15 2025
End Date
December 15 2028
Last Update
May 28 2025
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