Status:
RECRUITING
Empowering Patients to Improve Safety in Polymedication
Lead Sponsor:
Leiden University Medical Center
Collaborating Sponsors:
University of Ljubljana
RWTH Aachen University
Conditions:
Polypharmacy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Rationale: In current clinical practice, polypharmacy and patient empowerment are critical yet often overlooked. Polypharmacy, the chronic use of five or more drugs, poses risks such as adverse drug r...
Eligibility Criteria
Inclusion
- In order to be eligible to participate in this study, a subject must meet all of the following crite-ria:
- Polypharmacy defined as the use of 5 or more drugs
- Start usage of at least one index drug according to the list in table 3.
- Subject must be ≥ 18 years old
- Subject is able and willing to take part and be followed-up for at least 12 weeks
- Subject is able to donate blood or saliva
- Subject has signed informed consent
- A potential subject who meets any of the following criteria will be excluded from participation in this study:
- Pregnancy or lactating
- Life expectancy estimated to be less than three months by treating clinical team
- Unable to consent to the study
- Unwilling to take part
- Subject has no fixed address
- Subject has previously been genotyped for PGx genes
- Subject has no current general practitioner
- Subject is, in the opinion of the Investigator, not suitable to participate in the study
- Estimated glomerular filtration rate (MDRD) of less than 15 ml/min per 1,73m2
- Patients with advanced liver failure (stage Child-Pugh C)
Exclusion
Key Trial Info
Start Date :
July 27 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2026
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06956820
Start Date
July 27 2025
End Date
August 1 2026
Last Update
December 30 2025
Active Locations (4)
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1
Universitatsklinikum Aachen
Aachen, Germany, 52074
2
Universitatsklinikum Heidelberg
Heidelberg, Germany, 69120
3
University Hospital Patras
Pátrai, Greece, 26504
4
University Hospital Ljubljana
Ljubjana, Slovenia