Status:
ACTIVE_NOT_RECRUITING
Efficacy of Dextromethorphan-Bupropion Versus SSRIs in the Treatment of Major Depressive Disorder
Lead Sponsor:
Asad Ullah Jan
Collaborating Sponsors:
CMH Nowshera
Conditions:
Major Depressive Disorder (MDD)
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The study aims to compare the antidepressant effects of a dextromethorphan-bupropion combination versus standard SSRI therapy in adult patients with major depressive disorder. Participants will be ran...
Eligibility Criteria
Inclusion
- Diagnosed with major depressive disorder (MDD) per DSM-5 criteria.
- Baseline depression score indicating moderate to severe depression
- Ability to provide informed consent
- Willing to comply with study requirements
Exclusion
- History of bipolar disorder, schizophrenia, or other psychotic disorders
- Current substance use disorder (within past 6 months)
- Active suicidal ideation requiring urgent intervention
- Pregnancy or breastfeeding
- Known hypersensitivity to study medications
Key Trial Info
Start Date :
May 6 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2025
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06957223
Start Date
May 6 2025
End Date
December 31 2025
Last Update
July 9 2025
Active Locations (2)
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1
Combined Military Hospital
Nowshera, KPK, Pakistan, 25770
2
Department of Psychiatry, Combined Military Hospital Nowshera
Nowshera, KPK, Pakistan, 25770