Status:
COMPLETED
Observation on the Therapeutic Effect of Low-Intensity Transcranial Ultrasound Stimulation Combined With Upper Limb Virtual Reality Training on Post-Stroke Depression
Lead Sponsor:
Anhui Medical University
Conditions:
Post Stroke Depression
Stroke
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Abstract: objective:To study whether post-stroke depression can be improved through low-intensity transcranial ultrasound stimulation combined with upper limb virtual reality training, explore its po...
Detailed Description
Abbreviation：Transcranial Ultrasound Stimulation(TUS),low intensity focused ultrasound (LIFU),low intensity transcranial Ultrasound stimulation(LITUS),virtual reality(VR),post-stroke depression(PSD),W...
Eligibility Criteria
Inclusion
- The inclusion criteria were as follows:
- First-time stroke patients diagnosed with ischemic stroke via imaging techniques such as CT or MRI;
- Duration of the disease between 15 days and 6 months, with stable condition;Age between 18 and 75 years;
- Patients without severe intellectual, language comprehension, or behavioral impairments, capable of completing scale assessments, with an MMSE score of ≥24;
- Hemiplegia on one side and at least a 3rd-level seated balance, with Brunnstrom stage II or higher for the upper limb，able to perform movements with the assistance of the upper limb virtual reality training；
- No use of antidepressant medications in the past month, with PHQ-9 score≥10 and HAMA score≥17；
- Patients who are aware of the study details and have signed the informed consent form.
Exclusion
- The exclusion criteria were as follows:
- Patients with metallic implants in the cranium or those with a pacemaker;
- Patients with unstable conditions, multiple brain infarctions, severe heart disease, or other significant organ conditions and complications, or a history of cancer.
Key Trial Info
Start Date :
January 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 31 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06957340
Start Date
January 1 2023
End Date
October 31 2024
Last Update
May 4 2025
Active Locations (1)
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1
Anhui medical University
Hefei, Anhui, China, 230000