Status:
RECRUITING
Reconstructive Treatment of Peri-implantitis With Combined Defects
Lead Sponsor:
Gazi University
Conditions:
Peri-implantitis
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The aim of this randomized clinical study is to assess the additional clinical benefit of incorporating a resorbable collagen membrane (CM) alongside a xenogeneic bone graft-specifically, deproteinize...
Detailed Description
Reconstructive surgical therapy for peri-implantitis has shown improved clinical and radiographic outcomes, with favorable postoperative mucosal margin levels and superior radiographic bone fill compa...
Eligibility Criteria
Inclusion
- Peri-implantitis defined as the presence of a peri-implant probing pocket depth (PPD) ≥6 mm with bleeding and/or suppuration on probing (BoP/SoP) and radiographic marginal bone loss (MBL) ≥3 mm.
- Presence of combined defect configuration Class \[Ib, Ic, Ie with horizontal components (i.e. Class II) (Schwarz et al., 2010)\] with an intrabony compartment of ≥3 mm.
- Presence of a minimum width of 2 mm of keratinized peri-implant mucosa on the buccal aspect of the implant.
- Implants placed in proper position (inside the bony housing)
- Having an implant-supported prosthesis that allows for adequate oral hygiene procedures and peri-implant probing.
Exclusion
- Full-mouth plaque score (FMPS) \< 25%
- Full-mouth bleeding score (FMBS) \< 25%
- Cigarette smoking \< 10 cig./day,
- Diagnosed with active periodontal disease,
- Having acute or chronic medical conditions or undergoing medications, such as intravenous amino-bisphosphonates, immunosuppressive drugs, and chemotherapy, that could interfere with the treatment outcome,
- Receiving antibiotic treatment in the previous 3 months.
Key Trial Info
Start Date :
April 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06957652
Start Date
April 1 2025
End Date
December 1 2026
Last Update
May 4 2025
Active Locations (1)
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1
Gazi University Faculty of Dentistry
Ankara, Turkey, Turkey (Türkiye), 06490