Status:
NOT_YET_RECRUITING
Procalcitonin Aided Antimicrobial Therapy vs Standard of Care
Lead Sponsor:
Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Collaborating Sponsors:
Thermo Fisher Scientific FS
Conditions:
Lower Respiratory Tract Infection (LRTI)
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Antibiotic resistance is driven by overuse, especially for viral respiratory infections. Procalcitonin (PCT), a biomarker for bacterial infections, helps guide antibiotic therapy more precisely, reduc...
Detailed Description
Antibiotic resistance (ABR) poses a significant threat to global health and is largely driven by the overuse of antibiotics, particularly for acute respiratory tract infections (ARTIs), which are most...
Eligibility Criteria
Inclusion
- age ≥18 years;
- clinical and instrumental diagnosis of LRTI consistent with bacterial origin and requiring antimicrobial treatment;
- patient hospitalized in Internal Medicine, Geriatrics, Infectious Disease unit, Pneumology, Semi Intensive Care unit, ICU, Emergency Medicine;
- informed consent provided by the patient.
Exclusion
- age \< 18 years;
- lack of informed consent;
- severe immunosuppression (other than related to corticosteroid use);
- concomitant diagnosis of other infections requiring long term antimicrobial therapy (i.e. endocarditis, osteomyelitis)
Key Trial Info
Start Date :
June 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2027
Estimated Enrollment :
108 Patients enrolled
Trial Details
Trial ID
NCT06960044
Start Date
June 1 2025
End Date
June 1 2027
Last Update
May 7 2025
Active Locations (1)
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1
Clinical Trial Center
Alessandria, Piedmont, Italy, 15121