Status:
RECRUITING
The Effect of Hyaluronic Acid Injection on TNF-Alpha and IL-1β in Knee Osteoarthritis
Lead Sponsor:
Istanbul University
Collaborating Sponsors:
Istanbul University Research Fund
Conditions:
Knee Osteoarthritis
Hyaluronic Acid
Eligibility:
All Genders
45-75 years
Phase:
NA
Brief Summary
In this study, the effect of intra-articular HA injection therapy on pre- and post-treatment TNF-alpha and IL-1beta levels and methylation changes in blood and synovial fluid in patients with knee ost...
Eligibility Criteria
Inclusion
- Diagnosis of knee osteoarthritis according to ACR (American College of Rheumatology) criteria
- Knee pain for more than 3 months
- Presence of knee pain resistant to conservative treatment for at least 3 months
- To be between the ages of 45-75
- Kellgren-Lawrence stage 2-3 gonarthrosis detected in the available knee direct radiographs of the patients
Exclusion
- Patients with KL stage 1 and 4 OA
- Systematic diseases (severe cardiovascular disease, severe renal failure, severe hepatic failure, uncontrolled diabetes, cancer, immunosuppression, haematological diseases, systemic bone diseases)
- Bleeding tendency (acquired or inherited) \[lNR\>2 in a patient on Coumadin\],
- Infection (systemic or local)
- Secondary knee osteoarthritis (inflammatory joint disease, post-traumatic, post-infectious, etc.)
- Major knee trauma within the last 1 year
- BMI \>40
- History of total knee or hip arthroplasty within 1 year
- Pregnancy
- History of intra-articular injection within the last 6 months
- Patients with Hb less than 11 g/dl and Plt less than 150.000
- Presence of allergy to hyaluronic acid products
Key Trial Info
Start Date :
May 12 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 29 2026
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06960564
Start Date
May 12 2025
End Date
March 29 2026
Last Update
January 9 2026
Active Locations (1)
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1
Istanbul University, Istanbul Faculty of Medicine
Istanbul, Turkey (Türkiye)