Status:
RECRUITING
Test of Target Engagement of Ambiguity Aversion
Lead Sponsor:
Northwestern University
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Intolerance of Uncertainty
Anxiety
Eligibility:
All Genders
25-60 years
Phase:
NA
Brief Summary
The present work aims to test whether a single session intervention alters ambiguity aversion, both in terms of people's decision making and their brain responses to ambiguous choices.
Detailed Description
In this trial, participants will be randomized to one of two single session interventions (SSI). They will complete a decision making task before and after the SSI to measure their behavioral and brai...
Eligibility Criteria
Inclusion
- Ages 25 to 60
- Right-handed
- Ability to read and write English
- Capacity to provide informed consent
- Intolerance of uncertainty score ≥ -0.5 standard deviation below the mean (31st percentile)
Exclusion
- Personal history of psychosis, mania, or hypomania
- Personal history of autism spectrum disorder
- IQ \< 80 as determined by the Wechsler Test of Adult Reading
- Head injury with greater than 120 seconds loss of consciousness
- Neurological condition (e.g., epilepsy, Parkinson's, cerebral palsy, history of stroke)
- Currently pregnant
- Use of any implanted electrical device (e.g., pacemaker, spinal stimulator, vagal nerve stimulator, Inspire sleep apnea device, etc.).
Key Trial Info
Start Date :
July 7 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2029
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT06962527
Start Date
July 7 2025
End Date
December 31 2029
Last Update
November 21 2025
Active Locations (1)
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1
Northwestern University
Chicago, Illinois, United States, 60611