Status:
RECRUITING
Protocol Assessment of Motor Cortex rTMS for Treating Neuropathic Pain
Lead Sponsor:
Institut pour la Pratique et l'Innovation en PSYchologie appliquée (Institut Pi-Psy)
Conditions:
Chronic Pain Syndrome
Peripheral Neuropathic Pain
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Neuropathic pain is frequent and drugs relieves only 50% of the patients. Repetitive transcranial magnetic stimulation (rTMS) at high frequency (HF, usually 10Hz) applied on the primary motor cortex (...
Detailed Description
Description of the research proceedings and study design This is a 3-parallel-group monocentric randomized study, in which 36 patients, aged between 18 and 80 years, suffering from painful peripheral ...
Eligibility Criteria
Inclusion
- (1) existence of a definite peripheral neuropathy on both clinical and neurophysiological grounds, present for at least 6 months;
- (2) neuropathic pain clearly related to the neuropathy, as defined by a score ≥ 4/10 on the questionnaire "Douleur Neuropathique en 4 Questions" (DN4) ;
- (3) a score ≥ 4/10 on a 0-10 numerical rating scale (NRS) concerning the average intensity of daily ongoing pain;
- (4) age between 18 and 80 years;
- (5) affiliation with the social security system;
- (6) ability to provide signed informed consent.
Exclusion
- (1) concomitant neurological (neurodegenerative disorders, migraine, epilepsy, stroke, tumor) or psychiatric illness;
- (2) contraindications related to TMS (intracranial ferromagnetic material);
- (3) drug-resistant or active epilepsy.
Key Trial Info
Start Date :
April 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2027
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT06964243
Start Date
April 1 2025
End Date
February 1 2027
Last Update
May 9 2025
Active Locations (1)
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1
Henri Mondor University Hospital
Créteil, Île-de-France Region, France, 94000