Status:
RECRUITING
Intermittent Hypoxia-Hyperoxia Combined With Physical Therapy for Knee Osteoarthritis
Lead Sponsor:
Khyber Medical University Peshawar
Collaborating Sponsors:
Rehman Medical Institute - RMI
Conditions:
Osteo Arthritis Knee
Eligibility:
All Genders
45+ years
Phase:
NA
Brief Summary
This randomized controlled trial aims to evaluate the effectiveness of combining intermittent hypoxia-hyperoxia therapy (IHHT) with conventional physical therapy in improving pain, function, gait, bal...
Detailed Description
Osteoarthritis (OA) is a prevalent chronic condition that leads to joint pain, stiffness, and impaired mobility, particularly among middle-aged and elderly populations. In Pakistan, knee OA is common ...
Eligibility Criteria
Inclusion
- Participants aged 45 and above.
- Participants (both male and female) with knee pain for 3 months or more with any three of the following six items: age of 50 years or more, crepitations, enlarged bone, no palpable warmth, morning stiffness for less than 30 minutes, and bony tenderness.
- Patients who can walk and have a minimum score of 4 on the Numeric Pain Rating Scale.
- Participants who have intact cognition with a score of 24 and above on Mini Mini- Mental State examination.
- Participants able to walk independently for at least 45 meters in the 6-minute walk test.
- Participants having a recent X-ray (done within the past 3 months).
Exclusion
- Patients with hip or knee arthroplasty.
- Participants with above or below knee surgery or radiating pain to the lower limb.
- Patients with history of epilepsy, pregnancy
- Diagnosed neurological condition that affects lower-limb strength or walk (e.g., stroke/ basal ganglia dysfunction/ trauma)
- Patients who refused to participate in the study or to be randomly allocated.
- Patients receiving steroids or any medicine other than that prescribed by the screening orthopaedic surgeon.
Key Trial Info
Start Date :
May 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 30 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06965946
Start Date
May 15 2025
End Date
November 30 2025
Last Update
September 2 2025
Active Locations (1)
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1
Rehman Medical Institute
Peshawar, Khyber Pakhtunkhwa, Pakistan, 25000