Status:
NOT_YET_RECRUITING
This Randomized, Clinical Trial Evaluates the Efficacy of Oral Versus Sublingual Vitamin B12 Supplementation in Correcting Early-onset Vitamin B12 Deficiency in Adult Patients Using Proton Pump Inhibitors (PPIs). The Primary Outcome is the Change in Serum Vitamin B12 Levels Over a 6-week
Lead Sponsor:
Tanta University
Conditions:
Hypovitaminosis b 12
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
This randomized, clinical trial evaluates the efficacy of oral versus sublingual vitamin B12 supplementation in correcting early-onset vitamin B12 deficiency in adult patients using proton pump inhibi...
Eligibility Criteria
Inclusion
- Age 18-70.
- PPI use for 1-6 months (new users).
- Serum B12 between 150-300 pg/mL.
- No known prior B12 supplementation.
Exclusion
- History of long-term GI disease (e.g., Crohn's, celiac).
- Previous gastrectomy/bariatric surgery.
- Baseline anemia with hemoglobin \<9 g/dL.
- Severe renal or liver failure.
Key Trial Info
Start Date :
December 30 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2029
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT06966856
Start Date
December 30 2026
End Date
December 30 2029
Last Update
May 13 2025
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