Status:
COMPLETED
Endocrine Disruptors, Toxic and Essential Chemical Elements and Polycystic Ovary Syndrome
Lead Sponsor:
University Medical Centre Ljubljana
Conditions:
Polycystic Ovary Syndrome
Eligibility:
FEMALE
20-39 years
Brief Summary
Studies have shown that endocrine disruptors (EDs) and toxic and essential chemical elements affect women's reproductive health and may play a role in the development of polycystic ovary syndrome (PCO...
Detailed Description
Endocrine disruptors are externally introduced chemical substances or mixtures of substances that, through altering hormone functions, cause unwanted effects on the health of an individual or its offs...
Eligibility Criteria
Inclusion
- body mass index (BMI) between 18.5 and 29.9 kg/m2
- fulfilling two of the three Rotterdam diagnostic criteria for the diagnosis of PCOS: oligo- or anovulation, ultrasound-visible morphological picture of PCO (presence of 12 or more follicles of size 2-9 mm in one of the ovaries) and/or clinical/biochemical signs of hyperandrogenism (study group)
- a regular menstrual cycle of 21 to 35 days (control group)
Exclusion
- pregnancy
- hormonal treatment in the last 3 months (hormonal contraception, hormone replacement therapy, progestogens)
- hyperprolactinemia
- hypothyroidism, hyperthyroidism
- known premature ovarian failure, primary amenorrhea
- chronic diseases: diabetes, depression, Crohn's disease, celiac disease, cardiovascular diseases, liver and kidney disease, asthma, chronic obstructive pulmonary disease, diseases of the musculoskeletal system, neurological diseases, oncological diseases.
Key Trial Info
Start Date :
January 3 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2024
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT06968455
Start Date
January 3 2023
End Date
December 31 2024
Last Update
May 13 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Division of Ob/Gyn, University Medical Centre Ljubljana
Ljubljana, Slovenia, 1000