Status:
RECRUITING
Mechanical Dyssynchrony and Microvascular Dysfunction by SPECT
Lead Sponsor:
Tomsk National Research Medical Center of the Russian Academy of Sciences
Collaborating Sponsors:
Russian Science Foundation
Conditions:
Myocardial Blood Flow Reserve
Mechanical Dyssynchrony
Eligibility:
All Genders
18-75 years
Brief Summary
The project is aimed at studying the feasibility of mechanical dyssynchrony of the left ventricle of the heart, determined by SPECT (gated MPI), as well as its stress-induced dynamics, in the evaluati...
Detailed Description
Each patient will have a peripheral catheter placed, blood will be drawn, followed by dynamic SPECT on a two-day rest/stress protocol, and then standard gated myocardial perfusion scintigraphy will be...
Eligibility Criteria
Inclusion
- Ischemia with no obstructive coronary arteries (INOCA)
- Obstructive coronary artery disease (CAD)
- Patients without evidence of coronary heart disease
Exclusion
- Left ventricular ejection fraction \<55% according to echocardiography;
- History of myocardial infarction/revascularization;
- hypertension: systolic blood pressure \>180 mm Hg. Art., diastolic BP\>110 mm Hg. Art.;
- systolic arterial hypotension \<80 mm Hg. Art.;
- atrial fibrillation;
- AV blockade of the III degree; sick sinus syndrome;
- massive pulmonary embolism (PE) with a high degree of pulmonary hypertension;
- the presence of significant valvular pathology (mitral insufficiency ≥ 3 degrees, aortic insufficiency ≥ 3 degrees, tricuspid regurgitation ≥ 3 degrees).
- severe course of bronchial asthma, chronic obstructive pulmonary disease;
- decompensated type 2 diabetes,
- severe liver or kidney failure (glomerular filtration rate \<50 ml/min/1.73 m3 (CKD-EPI),
- morbid obesity (body mass index \>45);
- history of myocarditis
- indications of poor drug tolerance;
- oncological diseases;
- chronic alcoholism, mental disorders;
- other severe comorbidity,
- refusal to participate in the study.
Key Trial Info
Start Date :
October 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 15 2026
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT06969547
Start Date
October 1 2023
End Date
May 15 2026
Last Update
September 24 2025
Active Locations (1)
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1
Tomsk NRMC Cardiology Research Institute
Tomsk, Russia, 634012