Status:
COMPLETED
EVALUATION OF SALIVARY BİOMARKER LEVELS IN SMOKING AND NON-SMOKER INDIVIDUALS WITH DIFFERENT PERIODONTAL DISEASES
Lead Sponsor:
Izmir Katip Celebi University
Conditions:
Periodontal Diseases
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This study aimed to compare various cytokine levels in saliva samples in order to understand the pathogenesis of chronic inflammatory diseases. In particular, HMGB1, sTREM-1 and TNF-α levels were exam...
Detailed Description
This clinical study aims to comparatively investigate the salivary levels of HMGB1, sTREM-1, and TNF-α in individuals with periodontitis who smoke and do not smoke, as well as in non-smoking individua...
Eligibility Criteria
Inclusion
- Systemically healthy (Determination of volunteers will be based on patient statements in the anamnesis. No additional examination will be performed.)
- At least 16 permanent teeth in the mouth
- For non-smoking groups: never smoked
- For the smoking group: smoking at least 10 cigarettes per day
- No continuously used medications
- No use of antibiotics, anti-inflammatory drugs, and systemic corticosteroids in the last 6 months
- Not pregnant or breastfeeding
- No periodontal treatment in the last 6 months
- For the Periodontitis group: based on the evaluation of 6 sites per tooth, ≥30% bleeding on probing, probing depth ≥5 mm and clinical attachment loss ≥4 mm in at least 2 non-adjacent teeth in a quadrant, and radiographic bone loss of coronal 1/3 or more (horizontal and/or vertical)
- For the Gingivitis group: based on the evaluation of 6 sites per tooth, ≥10% bleeding on probing, probing depth \<4 mm, and no clinical attachment loss
- For the Healthy group: based on the evaluation of 6 sites per tooth, \<10% bleeding on probing, probing depth \<4 mm, and no clinical attachment loss.
Exclusion
- Any oral or systemic disease
- Regularly using a systemic medication
- During pregnancy or lactation
- Received periodontal treatment within the last 6 months.
- Those who received antibiotic, anti-inflammatory or systemic corticosteroid medication in the last 6 months
Key Trial Info
Start Date :
April 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2025
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06971770
Start Date
April 1 2024
End Date
February 1 2025
Last Update
May 14 2025
Active Locations (1)
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1
Izmir Katip Çelebi University Department of Periodontology
Izmir, Çiğli, Turkey (Türkiye), 35640