Status:
NOT_YET_RECRUITING
Tumor Associated Neutrophils as a Biomarker of Chemo-immunotherapy Response in Locally Advanced Non-small Cell Lung Cancer : a Model Based on Neoadjuvant Strategy
Lead Sponsor:
University Hospital, Montpellier
Conditions:
Non-Small Cell Lung Cancer
Eligibility:
All Genders
18+ years
Brief Summary
evaluate the predictive value of circulating neutrophil DNA methylation profiles, identified from the ALCINA 2 cohort, on pre-treatment blood samples (T0), for the histological response to neoadjuvant...
Eligibility Criteria
Inclusion
- Age ≥ 18 years.
- Resectable non-small cell lung cancer (NSCLC), stage IIA to IIIB.
- Lymph node status obtained by Positron Emission Tomoscintigraphy (PET)-scanner, confirmation of lymph node status by optional histological sampling (mediastinoscopy, thoracoscopy, echo-endoscopy).
- No secondary lesions in the cerebrum or extra-cerebrum confirmed on brain MRI, PET scanner +/- injected cerebro-thoraco-abdomino-pelvic scanner.
- Neoadjuvant immunochemotherapy strategy validated by a multidisciplinary consultation meeting (RCP) prior to the start of treatment.
- Lung function compatible with thoracic surgery, patient meets surgical and anesthetic criteria for operability
- Measurable disease according to RECIST criteria version 1.1
Exclusion
- Previous systemic treatment for the same CBNPC.
- Diagnosis of another solid tumor within the last 3 years, ‡ excluding non melanoma cutaneous and cervical carcinomas .
- Contraindication to immunotherapy.
- Non-objection to participate in research not collected.
- Patients unable to read and/or write.
- Inability to monitor patient during study period
- Persons unable to express their consent.
- Not affiliated to a social security scheme.
- Persons under court protection.
- Persons participating in another research study with an ongoing exclusion period.
- Pregnant women
Key Trial Info
Start Date :
July 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2028
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT06974097
Start Date
July 1 2025
End Date
December 30 2028
Last Update
July 8 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
CHU de Montpellier - Hôpital Arnaud de Villeneuve
Montpellier, Cedex 5, France, 34295