Status:
NOT_YET_RECRUITING
Rapid Antidepressant Dynamics in Acute Neuromodulation Treatments
Lead Sponsor:
Marta Peciña, MD PhD
Conditions:
Depression
Major Depressive Disorder
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
The goal of this clinical trial is to learn how different types of non-invasive brain stimulation affect mood and brain function in adults with major depressive disorder (MDD). It will also study how ...
Detailed Description
This mechanistic clinical trial will investigate the role of large-scale brain networks in modulating mood responses in adults with major depressive disorder (MDD) using non-invasive neuromodulation a...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Adults ages 18-55 (\~60% female).
- Diagnosis of Major Depressive Disorder (MDD) with or without comorbid anxiety disorders (e.g., panic disorder) or Axis II disorders.
- Psychotropic-free at enrollment.
- Exclusion Criteria:
- being pregnant or breastfeeding;
- diagnosis of psychotic depression, schizophrenia, bipolar disorder, or other Axis I disorders, except for anxiety disorders;
- severe substance use (excluding nicotine) in the last 2 months as determined by using the MINI, a structured interview that uses the Diagnostic and Statistical Manual of Mental Disorders;
- requiring immediate hospitalization;
- epilepsy or conditions requiring an anticonvulsant;
- receiving vagus nerve stimulation, electroconvulsive therapy (ECT), or TMS in the last 2 months;
- currently taking or have taken within the last 21 days psychiatric medication or augmenting agents;
- receiving depression-specific psychotherapy;
- actively suicidal or considered a high suicide risk;
- enrolled in another study; or
- MRI/TMS contraindication as determined by the fMRI and TMS screening questionnaires
Exclusion
Key Trial Info
Start Date :
April 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2030
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06976840
Start Date
April 1 2026
End Date
August 1 2030
Last Update
January 7 2026
Active Locations (1)
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1
Bellefield Towers
Pittsburgh, Pennsylvania, United States, 15213