Status:
NOT_YET_RECRUITING
Investigating the Impact of Sepsis Phenotypes on Antibiotic Treatment in Patients With Severe Pneumonia and Sepsis
Lead Sponsor:
University of Manchester
Conditions:
Respiration Disorders
Respiratory Failure
Eligibility:
All Genders
18+ years
Brief Summary
Aim of the research: To find out why antibiotics work differently in certain patients with severe pneumonia and sepsis. Background: Individuals can become very unwell from pneumonia, sometimes requir...
Eligibility Criteria
Inclusion
- age ≥ 18 years;
- admitted to intensive care and receiving at least one-organ supportive care;
- treated for presumed or confirmed lower respiratory infection;
- receiving or about to receive piperacillin/tazobactam as part of standard clinical care;
- valid informed consent or enrolment through deferred consent pathway appropriate.
Exclusion
- unlikely to survive 24 hours as judged by the treating physician;
- study antimicrobial started more than 24 hours prior.
Key Trial Info
Start Date :
September 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 30 2027
Estimated Enrollment :
119 Patients enrolled
Trial Details
Trial ID
NCT06977165
Start Date
September 1 2025
End Date
September 30 2027
Last Update
May 18 2025
Active Locations (1)
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1
The University of Manchester
Manchester, Lancashire, United Kingdom, M13 9PL