Status:
NOT_YET_RECRUITING
Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Brown Adipose Tissue (BAT) Physiology
Cold Exposure
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
The purpose of the study is to asses brown adipose tissue activity after a cold mild stimulus, preceded by 200mg caffeine or placebo administration.
Detailed Description
Brown adipose tissue (BAT) activation is typically through beta3-adrenoceptors (beta3-AR), but beta3-alone are less efficacious than cold in activating human BAT. Recent research suggests that adenosi...
Eligibility Criteria
Inclusion
- BMI 18.5 to 25 kg/m2
- Able to give informed consent as documented by signature
- Moderate caffeine consumption (1 to 3 cups of coffee per day)
- Increase of EE in response to mild cold of ≥ 5% of REE
Exclusion
- Known hypersensitivity or allergy to caffeine
- Concomitant medication other than prescription free analgesics (paracetamol and NSAID) and oral contraceptives
- Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, cardiac arrhythmia, hypertension, diabetes mellitus, hyper- or hypothyroidism)
- History of depressive disorder or anxiety disorder
- Smoker / habitual tobacco use
- Habitual excessive alcohol use
- Regular consumption of caffeine containing energy drinks
- Weight change of \>5% within 3 months prior to inclusion
- Systolic blood pressure \>140 mmHg and/or diastolic blood pressure \> 95 mmHg.
- Resting heart rate \>90 bpm
- Hypersensitivity to cold (e.g. Raynaud syndrome)
- Known or suspected non-compliance, drug or alcohol abuse
- Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant.
- Enrolment of the investigator, his/her family members, employees, and other dependent persons
- Enrolment into another study using ionizing radiation within the previous 12 months.
- Pregnancy or lactation
Key Trial Info
Start Date :
January 15 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT06978777
Start Date
January 15 2026
End Date
December 31 2026
Last Update
November 25 2025
Active Locations (1)
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1
University Hospital Basel, Department of Endocrinology
Basel, Switzerland, 4031