Status:
NOT_YET_RECRUITING
Pegylated Liposomal Doxorubicin (PLD) Versus Active Surveillance for Advanced Soft Tissue Sarcoma Patients Who Had Controlled Disease After Standard Anthracycline-based Treatment (MELODY)
Lead Sponsor:
National Health Research Institutes, Taiwan
Collaborating Sponsors:
National Taiwan University Hospital
Chang Gung Memorial Hospital
Conditions:
Advanced Soft Tissue Sarcoma
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Maintenance Pegylated Liposomal Doxorubicin (PLD) Versus Active Surveillance for Advanced Soft Tissue Sarcoma Patients Who Had Controlled Disease After Standard Anthracycline-based Treatment (MELODY)
Detailed Description
Patients enrolled will be randomized to either experimental arm or control arm. Patients in experimental arm will receive pegylated liposomal doxorubicin (PLD) 40mg/m2 every 4 weeks. Maintenance PLD c...
Eligibility Criteria
Inclusion
- A histologically confirmed advanced soft tissue sarcoma. Note that subtypes typically do not use chemotherapy as standard treatment are not allowed, such as alveolar soft part sarcoma, solitary fibrous tumor, extraskeletal myxoid chondrosarcoma, clear cell sarcoma)
- Patients received first-line anthracycline-based treatment for a minimum of 4 cycles and a maximum of 8 cycles.
- The best response after first-line anthracycline-based treatment must be either a complete response, partial response, or stable disease as defined by RECIST 1.1.
- The best response should be attributed solely to systemic treatment and not to local therapy. All the patients must have at least one measurable tumor based on RECIST 1.1 before initiating first-line anthracycline-based treatment.
- Patients must be randomized within 8 weeks of their last dose of anthracycline-based treatment
- Patients have a life expectancy ≥ 3 months
- Patients older than 18 years old.
- ECOG performance status of 0 to 1.
- Patients must have adequate organ function and marrow reserve measured within 7 days prior to randomization as defined below:
- Hemoglobin ≥ 9.0 g/dL;
- Absolute neutrophil count ≥ 1,500/mm3;
- Platelets ≥ 100,000/mm3;
- Total bilirubin ≤ 1.5 x upper normal limit;
- AST(SGOT)/ALT(SGPT) ≤ 2.5 x upper normal limit; for patients with liver metastases AST(SGOT)/ALT(SGPT) ≤ 5 x upper normal limit is allowed;
- Serum creatinine ≤ 1.5mg/dL or creatinine clearance ≥50ml/min;
- All women of childbearing potential must have a negative pregnancy test obtained within 72 hours before starting therapy.
- For male participants: agreement to remain abstinent (refrain from heterosexual intercourse) or use a condom, and agreement to refrain from donating sperm.
- Patients with reproductive potential must use effective contraception (hormone orbarrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 6 months after the completion of therapy.
- Patients must be able to comply with study procedures and sign informed consent.
Exclusion
- Known allergy history to PLD or other drugs of liposome-based formulation.
- LVEF \< 50% at screening as determined by UCG or MUGA.
- Serious non-healing wound, ulcer, or bone fracture not related to underlying sarcoma.
- Major surgical procedure, open biopsy, significant traumatic injury, or radiotherapy within 21 days prior to randomization.
- Severe, uncontrolled medical conditions including severe liver disease, heart disease, uncontrolled diabetes or hypertension, or pulmonary disease.
- Psychiatric illness or social situation that would preclude study compliance.
- Women with pregnant or breast feeding (a urine pregnancy test must be performed on all female patients who are of childbearing potential before entering the study, and the result must be negative.
- Another previous malignancy diagnosed within the past 3 years. Patients with carcinoma in situ and stage I malignancy under active surveillance (no medical treatment needed) are allowed for enrollment.
- Active CNS metastasis defined by clinical symptoms, cerebral edema, steroid or anti- convulsant requirement, or progressive growth. Patients with a history of CNS metastasis or cord compression are allowed in the study if they have been treated and are clinically stable.
- Patients with active hepatitis B. However, patients with controlled hepatitis B under anti-viral agent are allowed.
Key Trial Info
Start Date :
July 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2029
Estimated Enrollment :
81 Patients enrolled
Trial Details
Trial ID
NCT06981637
Start Date
July 1 2025
End Date
July 31 2029
Last Update
May 21 2025
Active Locations (7)
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1
Chang Gung Memorial Hospital
Kaohsiung City, Taiwan
2
Kaohsiung Medical University Chung-Ho Memorial Hospital,
Kaohsiung City, Taiwan
3
China Medical University Hospital
Taichung, Taiwan
4
National Cheng Kung University Hospital
Tainan, Taiwan