Status:
RECRUITING
Effects of Fibres Combined With Probiotics on Uric Acid in an ex Vivo Fermentation Model
Lead Sponsor:
Örebro University, Sweden
Collaborating Sponsors:
University of Copenhagen
Conditions:
Hyperuricemia
Eligibility:
All Genders
18-80 years
Brief Summary
In this study, we will collect faecal samples from individuals with hyperuricaemia (assessed by blood test) and perform in vitro faecal fermentation studies to assess how probiotics in combination wit...
Detailed Description
In this study, the investigators will collect blood samples to check if recruited participants have hyperuricemia, and if yes, stool samples will be collected for laboratory faecal fermentation tests....
Eligibility Criteria
Inclusion
- Signed informed consent prior to any study-related procedures
- Age 18-80 years old
- BMI range 18.5-35 kg/m2
- Blood uric acid above 0.36 mmol/L (6 mg/dl)
- Willing to abstain from regular consumption of probiotic supplements or food products containing probiotic bacteria (including fermented food and beverages), until collection of faecal material
- Willing to abstain from regular consumption of supplements and medications known to alter gastrointestinal function or inflammatory status during the study, until collection of faecal material
Exclusion
- Diagnosis of type 1 and/or type 2 diabetes
- Diagnosed inflammatory bowel disease (IBD)
- Current diagnosis of psychiatric disease/s or syndromes
- Current diagnosis of neurodegenerative disease
- Current pregnancy or breastfeeding
- History of complicated gastrointestinal surgery
- Systemic use of antibiotics and/or steroid medication in the last 4 months prior to inclusion
- Regular use of any non-steroidal anti-inflammatory drug (NSAID) for the last 2 months
- Consumption of any NSAID within 3 days of sample collection
- Current (or within the last 4 weeks prior to study start) use of probiotic supplementation
- Any condition or intake of medication which could substantially interfere with the outcome of the study, as decided by the principal investigator's discretion
- After being included in the study and until collection of faecal material, starting any medication or treatment that could potentially influence the study participation and/or study analysis
Key Trial Info
Start Date :
June 12 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2028
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT06981663
Start Date
June 12 2025
End Date
December 1 2028
Last Update
August 12 2025
Active Locations (1)
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1
Örebro University
Örebro, Sweden