Status:
COMPLETED
Relationship Between Intestinal Flora Changes and Hyperuricemia Under Chronic Psychological Stress
Lead Sponsor:
Shanghai 10th People's Hospital
Conditions:
Hyperuricemia
Eligibility:
MALE
18-69 years
Brief Summary
To clarify the mechanism of stress on the incidence of hyperuricemia
Detailed Description
To clarify the differences in intestinal microorganisms and metabolism between healthy people and hyperuricemia patients and across different level of stress
Eligibility Criteria
Inclusion
- Obtain the informed consent of the subjects before conducting any trial-related activities;
- Males aged 18-69;
- The hyperurcemia group must meet the diagnostic criteria of having blood uric acid \>420umol/L measured twice on an empty stomach on different days under a normal purine diet;
Exclusion
- \- 1)Use of any uric acid-lowering drugs, anti-gout drugs, steroids, proton pump inhibitors, or non-steroidal anti-inflammatory drugs within one month before enrollment; 2)Use of any antibiotics, probiotics, or other drugs including traditional Chinese medicine within one month before enrollment; 3)Abnormal liver function, ALT and AST are more than 2.5 times the upper limit of normal; 4)Other diseases that affect glucose and lipid metabolism: hyperthyroidism, hypothyroidism, hypercortisolism, etc.
- 5)Chronic kidney disease or severe renal impairment, according to eGFR grading \<45mL/min/1.73m2; 6)Secondary hyperuricemia 7)Any gastrointestinal diseases
Key Trial Info
Start Date :
September 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2025
Estimated Enrollment :
67 Patients enrolled
Trial Details
Trial ID
NCT06984575
Start Date
September 1 2023
End Date
May 1 2025
Last Update
May 22 2025
Active Locations (1)
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1
Shanghai Tenth People's hospital
Shanghai, Shanghai Municipality, China, 200070