Status:
NOT_YET_RECRUITING
Grape Extract and Exercise Effects on Blood Pressure
Lead Sponsor:
University of Castilla-La Mancha
Collaborating Sponsors:
Alvinesa Natural Ingredients
Conditions:
Exercise Response
Blood Pressure Monitoring, Ambulatory
Eligibility:
All Genders
25-65 years
Phase:
NA
Brief Summary
Exercise and grape extract intake (i.e., polyphenol-rich product) can independently improve blood pressure and endothelial function in prehypertensive individuals. Nevertheless, their combined effects...
Eligibility Criteria
Inclusion
- Sedentary individuals (\<120 min·wk-1 of moderate-intensity activity assessed by 7-d IPAQ).
- Aged 25-65 years and BMI 18-35 kg/m2.
- Elevated BP (i.e., prehypertensive; systolic and diastolic BP between 120-139 and/or 80-89 mmHg, respectively)
Exclusion
- Weight instability (\>5kg change in body mass over last 6 months)
- Pregnant or lactating
- Changes in physical activity over the last 3 months and planning on physical activity, or diet throughout the intervention.
- Untreated cardiovascular or renal disease, peripheral vascular disease, hypertension (≥140 mmHg systolic, or ≥90 mmHg diastolic BP), and any disease associated with exercise intolerance.
- Under pharmacological treatment for any cardiometabolic disease (i.e., hypertension, dyslipidemia or hyperglycemia)
- Currently taking dietary supplements that influence the cardiovascular response (e.g., polyphenols, omega-3 fatty acids, Magnesium, nitrates, L-arginine, red ginseng, natto, ginkgo, CoQ10) or used in the last month.
- Current or recent use (within the past 6 months) of tobacco or nicotine-containing products, or illicit drugs.
- Any medical condition or medication that could introduce bias into the study (e.g. neurological disorders)
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT06985407
Start Date
October 1 2025
End Date
June 1 2026
Last Update
May 22 2025
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