Status:
COMPLETED
Effect to Linaclotide on Colonic Motility
Lead Sponsor:
Universitaire Ziekenhuizen KU Leuven
Conditions:
Chronic Constipation
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
This study aim was to evaluate the effect of Linaclotide, a pharmacological treatment normally used to treat functional constipation or irritable bowel syndrome with predominant constipation, on colon...
Detailed Description
Rationale: Several treatments with different modes of action are currently available for chronic constipation, including the osmotic laxative polyethylene glycol (PEG), the stimulant laxative bisacody...
Eligibility Criteria
Inclusion
- healthy male and non-pregnant, non-breastfeeding female participants, aged 18-65 years old at the time of consent
Exclusion
- use of medications within 48 h of dose initiation; structural or metabolic diseases that affect the gastrointestinal system and functional gastrointestinal disorders; previous abdominal surgery other than appendectomy, cholecystectomy, hysterectomy, or hernia repair; known illnesses such as diabetes, cardiovascular or lung disease; use of agents that influence bowel habit, i.e. anticholinergics (not including antihistamines with anticholinergic properties), spasmolytics and prokinetics in the 7 days before the study
Key Trial Info
Start Date :
February 10 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 3 2015
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT06989268
Start Date
February 10 2014
End Date
June 3 2015
Last Update
May 25 2025
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