Status:
COMPLETED
Impact of Perioperative Hyperoxia on Cancer Recurrence and Mortality After Elective Colorectal Cancer Surgery
Lead Sponsor:
Parc de Salut Mar
Conditions:
Recurrence
Survival Rate
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this observational study is to evaluate whether perioperative hyperoxia (FiO₂ \> 0.8), compared to conventional oxygen therapy (FiO₂ \< 0.4), is associated with increased cancer recurrence...
Detailed Description
In 2016, the World Health Organization (WHO) recommended the use of perioperative hyperoxia (FiO₂ \> 0.8) to reduce the risk of postoperative surgical site infections (SSIs). However, the WHO also hig...
Eligibility Criteria
Inclusion
- Patients over 18 years old;
- Scheduled for major elective colorectal surgery under general anaesthesia with tracheal intubation.
Exclusion
- Non-oncologic surgery or non-curative oncological surgery
- Pregnant or breastfeeding women
- Chronic obstructive pulmonary disease (forced expiratory volume in one second \<50% or in need of domiciliary oxygen thera-py)
- Acute coronary event or stroke during the previous six weeks (before the surgery)
- Chronic renal failure requiring renal replacement therapy;
- Predicted length of stay of less than one day;
- Any patient that has received general anaesthesia during the previous month.
Key Trial Info
Start Date :
May 17 2024
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 11 2025
Estimated Enrollment :
403 Patients enrolled
Trial Details
Trial ID
NCT06989346
Start Date
May 17 2024
End Date
April 11 2025
Last Update
May 25 2025
Active Locations (1)
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1
Hospital del Mar
Barcelona, Catalonia, Spain, 08003