Status:
RECRUITING
Smart Measurement of Circulating Tumor DNA
Lead Sponsor:
Erasmus Medical Center
Collaborating Sponsors:
Dutch Cancer Society
Leiden University Medical Center
Conditions:
Colorectal Neoplasms
Colorectal Neoplasms Malignant
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this study is to develop a blood-test which can detect colorectal cancer in early stages. Participants will be asked to take an extra blood test, which will be analyzed further in the lab...
Detailed Description
Lynch Syndrome (LS) carriers have a predisposition to develop various types of cancer, especially colorectal cancer (CRC) and endometrial cancer (EC). LS patients are advised to undergo surveillance b...
Eligibility Criteria
Inclusion
- (suspect) Lynch Syndrome carriers who:
- Have proven Lynch Syndrome (MMR-gene or EPCAM mutation), or have a proven microsatellite instability high (MSI-H)tumor;
- Are at least 18 years old; Have been diagnosed with any form of cancer at the time of inclusion, but have had no treatment yet;
- Have granted informed consent to participate in this study.
Exclusion
- (suspect) Lynch Syndrome carriers who:
- Are unwilling to undergo extra blood sampling;
- Are under the age of 18;
- Have no newly diagnosed tumors at time of inclusion;
- Have been treated for their tumor at time of inclusion;
- Are not able to read or understand Dutch language or are mentally not capable.
Key Trial Info
Start Date :
May 16 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2027
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06989814
Start Date
May 16 2025
End Date
February 1 2027
Last Update
August 11 2025
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Leiden University Medical Center
Leiden, South Holland, Netherlands, 2333ZG
2
Erasmus MC
Rotterdam, South Holland, Netherlands, 3015GD